Two-time Players champion Tiger Woods is expected to return to action, having missed the Arnold Palmer Invitational with a neck injury, while Justin Rose and Rory McIlroy will be among the players bidding to become the first British victor since Sandy Lyle in 1987.
Woods has a record eight wins at Bay Hill.
Corey Conners is playing this week on the strength of his early season success.
In his only other starts this year, Woods finished in a share of 20th place at the Farmers Insurance Open in late January followed by a T15 at the Genesis Open in mid-February.
Roger Sloan made it into the field as an alternate on Monday after Patton Kizzire withdrew.
"I'd like to send my regrets to the Palmer family and the Orlando fans", Woods posted.
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I think it's massive. "It's important we get to the quarter-final after reaching this stage past year ". On his touchline ban, Pochettino said: "You are going to see why tomorrow I am not going to talk".
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Tiger Woods last played in the World Golf Championships-Mexico Championship on February 24 in Mexico City.
"For the better part of four to six months, I had to be helped out of bed every day", Woods said in an interview with ESPN in March 2018, after finishing tied for fifth and 10-under par at the Arnold Palmer Invitational. "Its connection to Arnold makes it one of my favorite tournaments and I'm disappointed to miss it". The WGC Dell Match Play and the Masters are also less than six weeks away.
"We know Tiger would be here if he could and we look forward to having him return in the future", Arnold Palmer Invitational Tournament Director Marci Doyle said.
Woods is expected by many to compete for majors this year.
Woods, 43, is coming off a bounce-back season after years of health problems that included spinal fusion surgery.