A Fly Jamaica airliner crashed early Friday morning at the Cheddi Jagan International Airport, Timehri, officials said.
There were 82 Canadians on board on the plane, which was carrying 118 people, two infants and eight crew members.
But while airline officials reported two of the 128 people on the plane were taken to hospital as a precaution, Global Affairs said all Canadians on board were believed to be unhurt.
A hydraulic problem reportedly forced the pilots to return to the Georgetown Airport, just over 10 minutes after take-off.
The airport said on its Facebook page that the injuries were considered to be non-life-threatening, but otherwise offered no further details on the crash.
Images posted on the airport's Facebook page showed the nose of the Fly Jamaica Airways plane resting against a perimeter fence.
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The twin-engine jet skidded off the runway, injuring half a dozen people, according to the report.
Boeing said it was looking into the incident.
"I am all safe, but shaking", he wrote in a Facebook post. One of the aircraft's turbines is seen badly damaged after it apparently hit the barrier.
"We can confirm that Fly Jamaica flight OJ256 bound for Toronto returned to Georgetown with a technical problem and has suffered an accident on landing", the brief statement read.
On landing, the emergency services were activated and since then an investigator from the Guyana Civil Aviation Authority has taken responsibility for the crash site.
A spokesperson for Fly Jamaica said it is providing local assistance for its passengers and "will furhter release information as soon as it is available". The US National Transportation Safety Board was alerted.