He was the first Chinese leader of Interpol, which connects the law enforcement agencies of its 192 member countries.
Interpol President Meng Hongwei has been reported missing.
So far neither the public security ministry nor the foreign ministry in China has commented.
He also serves as a vice minister of public security in China, but he lives in Lyon, France, where Interpol is based, with his wife and children.
Meng's appointment as Interpol president in 2016 - amid Chinese leader Xi Jinping's sweeping anti-corruption drive - alarmed some human rights organizations, fearful it would embolden China to strike out at dissidents and refugees overseas.
China yesterday remained silent over the disappearance of the head of Interpol, deepening the mystery over the global police chief's fate after reports said he was detained for questioning on arrival in his homeland.
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A Hong Kong newspaper cited an anonymous source saying Mr Meng was taken away for questioning by "discipline authorities", a term that usually describes investigators in the ruling Communist Party who probe graft and political disloyalty.
Mr Meng's case is notable for a few reasons.
Presidents of Interpol are seconded from their national administrations and remain in their home post while representing the global policing body.
China has recently rolled out stiff anti-corruption measures establishing National Supervisory Commission which has powers to investigate public servants. At the General Secretariat of Interpol emphasize that the absence of the President should not affect the work of the worldwide police, because of its daily activities meet the Secretary-General jürgen Stock.
Roderic Broadhurst, a professor of criminology at Australian National University, said Meng's disappearance would be "pretty disconcerting" for people in worldwide bodies that work with China, and could ultimately damage China's efforts to develop cooperative legal assistance measures with other countries.
Meng was appointed the head of Interpol in 2016. "France is puzzled about the situation of Interpol's president and concerned about the threats made to his wife".
It's unclear if he was on official business in China. But on Thursday, Chinese tax authorities spoke publicly about her disappearance, ordering her and companies she represents to pay taxes and penalties totalling $130 million US.