Local daily La Nuova Sardegna said Clooney, 57, had been headed to a film set on Tuesday when his motorbike was hit by a vehicle.
Mr Clooney was driving from his rented villa in Punta Aldia to Capo Ceraso, on the Sardinian coast, where he is filming a TV series based on the Second World War novel Catch-22.
The Hollywood actor collided with a Mercedes auto on Tuesday morning while in Puntaldia, Sardinia, on the way to a TV set. A photo from the scene shows the car's smashed windshield.
Clooney was taken to a hospital and the injuries are not believed to be serious, according to La Nuova.
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He was joined by wife Amal Clooney and it has been reported that the pair left the hospital together in a private auto.
Local police are investigating the accident, Ansa said.
Calls and emails to Clooney's spokesman weren't immediately returned.
It was announced in April that the multi-talented star was reducing his role in the Hulu production so he could concentrate on his directing and producing credits.
They met when she attended one of his parties at his Lake Como mansion, and Wednesday in Venice a year later.